Abstract:ntestinal polyp segmentation has been shown to accurately locate the position of polyps in the colon, providing a basis for clinicians to determine whether cancerous changes have occurred and the likelihood of such changes. However, two challenges are still faced by existing intestinal polyp segmentation methods: (1) The performance of segmentation models is overly dependent on pixel-by-pixel annotated training samples; (2) Existing methods do not fully utilize limited annotated sample sets, often introducing redundant and irrelevant interfering information, making it difficult to address complex and variable intestinal polyp segmentation problems such as newly emerging and new lesions. To address these challenges, a new few-shot intestinal polyp segmentation method based on an interactive guidance network has been designed, utilizing a dual-branch network with support and query branches. First, the encoded features of the support image are divided into target foreground and background using the true mask of the support image, and self-attention is calculated on the foreground features to enhance the robustness of the target area features. Second, cross-attention between the support foreground and query mixed features is established to promote the separation of foreground and background in the query mixed features, reducing the interference of irrelevant background noise in the query mixed features. Finally, a prototype set is generated from the cross-fused features to guide the prediction of unknown area masks in the query branch. The superiority of the designed method has been verified through experiments conducted on bkai-igh-neopolyp, CVC-ClinicDB, and EndoTect_2020_Segmentation_Test_Dataset datasets.