Abstract:s: The photovolumetric pulse wave can reflect the concentration of blood glucose, so the accurate extraction of the photovolumetric pulse signal is of great significance for blood glucose monitoring. In this manuscript, we propose an optimized method for extracting the eigenvalues of the photovolumetric pulse, which can eliminate local abnormal signals and thus improve the accuracy of non-invasive glucose detection. The method decomposes the collected pulse wave signal into multiple sub-signals after removing the high and low frequency noises by Empirical Wavelet Transform (EWT). Then the two-by-two similarity discrimination calculation is performed on the decomposed sub-signals via Dynamic Time Warping (DTW) algorithm in order to identify and eliminate the abnormal sub-signals. The two data sets of retained and rejected abnormal sub-signals are established, and the relevant parameters are extracted for comparative analysis. The experimental results show that the standard deviation of the peak-to-peak value, the rate of rising branch, the rate of falling branch, and signal length are reduced by 31.6%, 14.8%, 44.2%, and 28.5%, respectively, via using the DTW algorithm. This indicates that the reliability of the extraction of the feature values can be improved by using this method. In addition, the collection stability of eigenvalues of photovolumetric pulse wave can be improved by 44.4%, which proves the practic ality and reliability of this method in the monitoring of non-invasive blood glucose.