Abstract:To address the precision requirements for pulmonary nodule detection in chest CT images, this study proposes an attention-enhanced U-Net network (Attention U-Net). The network integrates an encoder-decoder architecture with attention mechanisms, enhancing the extraction of critical features while suppressing irrelevant information to improve detection accuracy. The attention module adaptively weights multi-scale feature maps, enabling the model to focus on nodule regions and mitigate interference from noise. Experimental evaluations on the public LUNA16 dataset demonstrate that the proposed Attention U-Net significantly outperforms traditional methods, achieving higher accuracy and recall rates. Further validation on the clinical TCIA dataset confirms the network’s effectiveness and reliability in real-world applications. These results highlight the broad clinical potential of the Attention U-Net-based approach for pulmonary nodule detection in chest CT screening.